A method to amplify the effect of antibiotics with gold nanoparticles is developed



The amount of antibiotics required to inhibit the growth of bacteria has been reduced to 1/128 by using new fine gold particles for the bacteria 'antibiotic-resistant bacteria' that are becoming a global problem and for which drugs do not work. A study was published that reduced it to.

Controlling the pyridinium–zwitterionic ligand ratio on atomically precise gold nanoclusters allowing for eradicating Gram-positive drug-resistant bacteria and retaining biocompatibility --Chemical Science (RSC Publishing)

https://pubs.rsc.org/en/content/articlelanding/2021/SC/D1SC03056F

Going for gold to reduce antibiotic resistance
https://phys.org/news/2021-11-gold-antibiotic-resistance.html

There are many different types of bacteria, some of which are beneficial to humankind, such as lactic acid bacteria, and some of which are harmful, such as pathogenic Escherichia coli. Human beings have developed 'antibiotics ' that prevent the growth of harmful bacteria, but the bacteria have also acquired resistance to antibiotics with the power of evolution. In this way, humans and bacteria continue to play cat and mouse over each other's survival.

Bacteria that are ineffective against antibiotics are also called 'super bugs' because of their ability. The following articles explain in detail how super bugs are born and how scary they are.

Movie 'The Antibiotic Apocalypse Explained' --GIGAZINE that you can understand how scary the devil's super bug that antibiotics do not work



Antibiotic resistance is the greatest threat to improving lives today, as bacteria gaining antibiotic resistance can cause serious harm, such as increased medical costs and increased mortality. and ' announcement enough to, antibiotic-resistant bacteria is a pressing issue. A joint research team of the University of Leeds in the United Kingdom and the Southern University of Technology and Fudan University in China has announced a study on the use of 'gold', which has antibacterial activity, for these antibiotic-resistant bacteria.

The research team announced that nanoparticles composed of 25 gold atoms would destroy the cell wall of bacteria. The antibacterial action of specific gold nanoparticles has attracted attention among researchers, but existing research has shown that 'effective bacteria can also harm the human body.' Could not be resolved. However, in a newly published study, a method has been developed that exerts its effect on bacteria while minimizing its harmfulness.

The research team focused on the fact that 'bacterial cell walls are more strongly negatively charged than mammalian cells.' From this point, the research team thought that a strong positive charge would be preferentially attracted to bacteria, and achieved an inducing effect on bacteria by covering the gold nanoparticles with a substance called a positively charged 'ligand'. However, in this state, positively charged ligands are also attracted to healthy host cells, so by adding more positively and negatively charged ligands on top of that, adjusting the ratio of each to the bacteria. While ensuring effectiveness, we have made it easier for gold nanoparticles to pass through healthy organs such as the kidneys and be excreted from the body.



In an experiment conducted using 'methicillin-resistant Staphylococcus epidermidis (MRSE)', a type of Staphylococcus aureus having a multidrug resistance gene for which antibiotics do not work, MRSE was developed when the developed gold nanoparticles and antibiotics were combined. It was possible to reduce the amount of antibiotics required to inhibit the growth of staphylococcus aureus to 1/128.

Professor Dejian Zhou of the University of Leeds, who was the instructor of this paper, said, 'Although there is a wide range of research on nanomaterials that are effective against bacteria, most of the research is biocompatibility and stable excretion from the body. Ignore whether or not. These factors are important requirements for regulatory approval. In this study, we systematically adjusted the ratio of the two ligands to make it an effective antibacterial agent. Not only that, we have established a method to utilize gold nanoparticles as a mechanism to amplify the effects of antibiotics that have become ineffective. '

in Science, Posted by log1k_iy