Research results show that a single dose of the hallucinogenic component of Magic Mushroom 'halves chronic headaches'

Psilocybin contained in Magic Mushroom is a hallucinogenic ingredient that is strictly restricted by the laws of many countries including Japan, but in recent years, its effectiveness as a drug has been reviewed, such as being approved as a 'breakthrough therapy' for depression. In addition, the number of areas that have been legalized is increasing. A new experiment in which a very small amount of psilocybin was given to a person suffering from migraine revealed that 'a single dose of psilocybin may have a lasting therapeutic effect on chronic headaches.' did.

Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin | SpringerLink

Psilocybin & migraine: First of its kind trial reports promising results

A single dose of psilocybin has a lasting therapeutic effect on migraine headache, according to a new placebo-controlled study controlled-study-60793

It has often been pointed out that psilocybin is effective for headaches, but there has been no scientific evidence to support it. Therefore, a research team led by Associate Professor Emmanuel Sindler of Yale University School of Medicine conducted an experiment in people suffering from migraine to investigate the effect of psilocybin on chronic headache.

Associate Professor Schindler commented on the significance of the experiment: 'From my many years of experience in neuropharmacology research, I appreciate that hallucinogenic components help us to better understand how the human brain works. After reading the report, 'I took a drug containing hallucinogenic components such as sirocibin once or several times, and there was a continuous improvement in certain headache diseases,' and this drug was used for headaches. I thought it would be useful for clarifying the cause and establishing a new treatment method. '

Seven women and three men who suffered from frequent migraine headaches participated in the experiment and took two capsules containing the drug at two-week intervals. At this time, neither the participants nor the person in charge of the experiment could tell which was the capsule for placebo containing the placebo and which was the capsule containing psilocybin. According to the research team, this is the first double-blind, placebo-controlled study to investigate the relationship between psilocybin and migraine.

After that, a diary of the subjects who recorded the presence and degree of headache was examined, and it was confirmed that the frequency of migraine in the two weeks after taking the capsule was halved in the subjects who took psilocybin. In addition, we found that not only the frequency of migraine headaches, but also the severity of the pain and the dysfunction caused by migraine headaches were reduced by 30%.

Schindler emphasizes that the experiment is small and preliminary, and further research is needed to test the headache-suppressing effect of psilocybin. In addition, since even one migraine involves various factors such as the brain, immune system, heredity, and environment, there is no such thing as a 'silver bullet that works for all headaches.' He also notes that abuse of psilocybin can have serious physical and psychological consequences.

'In this study, psilocybin was given only once and the dose was minimally low, but even at doses that caused little or no hallucinations,' Sindler said. Over the next few weeks, migraine headaches were alleviated and no serious side effects were seen, so psilocybin and psilocybin-related compounds should now be counted as treatment options for migraine headaches. It may be. '

in Science, Posted by log1l_ks