May 21, 2021 08:00:00

The link between 'depression' and 'inflammation' is found in the largest ever study of 86,000 people

Depression is caused by the mind and mind, so it is difficult to distinguish it by physical changes, but it is said that the amount of stress hormones is measured from

sweat and earwax , and that depression causes deterioration of the brain. Research is being conducted to detect symptoms at an early stage, such as judging from the appearance of images and the tendency of humor. The largest study ever reported in May 2021 shows that the higher the risk of depression, the higher the level of 'inflammation' that appears in the body.

Psychiatry Online
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2020.20060947

Huge Study Finds Inflammation Could Be a Core Feature of Depression
https://www.sciencealert.com/huge-study-finds-inflammation-could-be-a-core-feature-of-depression

Depression is a psychogenic symptom, but its effects are widely known to spread to the body, part of the brain is altered, and research results have been published showing that it accelerates cell aging.

Report that depression 'accelerates cell aging' --GIGAZINE

As a study of such symptoms, the largest ever study of about 86,000 people in the United Kingdom found that people with depression have proteins in their blood that indicate activation of the inflammatory system. 'A detailed analysis of the data of 86,000 people may be behind the link between inflammation and depression,' said Professor Maria Pisarolli, a psychologist at King's College London. I also discovered a mechanism. '

This study measured an inflammatory biomarker called C-reactive protein (CRP) in the blood. As a result, about 31% of individuals who reported having had major depressive disorder in the past found higher levels of CRP compared to those who did not.

From a genetic point of view, the genetic link between depression and inflammation was also investigated. Professor Cathryn Lewis, a geneticist at King's College London, said, 'Studies have shown that the genetic effects of depression on inflammation are primarily due to diet and smoking habits. It is important for understanding depression and can also help improve treatments for depression. '

In future studies, it is important to clarify the association between depression and inflammation as they coexist. If something that has not yet been discovered causes both symptoms, it will be possible to target the treatment of depression and the treatment will be greatly improved.

However, Professor David Curtis, a geneticist at King's College London who did not participate in this study, said, 'Past studies have shown that depression and physical illnesses, including inflammation, are related to each other. And this study is nothing new. It's doubtful that inflammation plays an important role in causing depression, 'he said. The study highlights the risks of high-risk 'anti-inflammatory drugs' being used to treat depression and recommends that you continue to use safe and effective antidepressants.