'Schizophrenia' is the next risk factor after age in the new corona



A new study of coronavirus disease (COVID-19) has shown that having schizophrenia is one of the biggest factors that increase the risk of death for COVID-19. This is the second-largest risk factor after age, and researchers commented, 'I was expecting it, but I was surprised.'

Association of Psychiatric Disorders With Mortality Among Patients With COVID-19 | Anxiety Disorders | JAMA Psychiatry | JAMA Network

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2775179

Schizophrenia is 2nd highest risk factor for dying of COVID-19, after age | Live Science
https://www.livescience.com/schizophrenia-covid-19-death-risk-factor.html

Previous studies have shown that people with psychiatric disorders such as depression and schizophrenia may be at increased risk of infection with the new coronavirus (SARS-CoV-2). However, the association with mortality has not yet been shown, so researchers at New York University have based on electronic health records registered at 260 outpatient clinics and four hospitals in New York City. Conducted a survey. The subjects were 26,540 people who tested for COVID-19 between March 3 and May 31, 2020, of which 7,348 were positive.

The research team categorized patients diagnosed with psychiatric disorders into three categories: schizophrenia spectrum disorders, mood disorders, and anxiety disorders, and compared them with patients who were not diagnosed with psychiatric disorders. In addition, adjustments were made for factors such as age, gender, race, and hypertension, diabetes, heart condition, chronic obstructive pulmonary disease, chronic kidney disease, smoking, and cancer, which are considered to be risk factors for COVID-19. That thing.



Of the patients diagnosed as COVID-19 positive in the survey, 75 had a history of schizophrenia, 564 had a mood disorder, and 360 had a history of anxiety disorder. Of the patients diagnosed with COVID-19, 864 died or could not be discharged within 45 days.

As a result of the investigation, it seems that no relationship was found between death due to COVID-19 and mood disorder / anxiety disorder, but on the other hand, those with a history of schizophrenia died 2.7 times more than those without mental disorder. The rate was high. This means that schizophrenia is the second risk factor after age.

Donald Goff, who conducted the research, commented, 'I expected them all, but it's also a surprise.' According to previous studies, patients with schizophrenia have a shorter life expectancy of 20 years than those who do not suffer from mental illness, and pneumonia and viral diseases are the most common causes of death. On the other hand, it is said that factors such as obesity, heart disease, and smoking are related to the cause of the short life expectancy of patients with schizophrenia, but it should be noted that these factors were adjusted in this study. Worth

Schizophrenia is thought to have the potential to alter a person's immune system and the body's immune response to infection, and Goff said that the schizophrenia disease itself or drugs can destroy the immune system, resulting in COVID-. We expect to increase the risk of 19 deaths. In addition, COVID-19 is thought to

cause an excessive production state of cytokines , but schizophrenia is also suspected to be related to cytokines.



However, the study points out that the number of patients with schizophrenia was small and that there was a lack of data on the patients' therapeutic agents, which researchers admit. It is also mentioned that the data were collected at the peak of the first wave of COVID-19, and that effective treatment was not clear at that time, resulting in an overall high mortality rate. 'Overall, absolute mortality is declining, but I think it's true that'schizophrenia patients are at high risk',' Goff said. He said.

in Science, Posted by darkhorse_log