Alcohol was produced in the female bladder
A woman was reported to have repeatedly tested positive for alcohol despite having refused alcohol before liver transplantation. Research has shown that the woman was using alcohol fermentation in her bladder.
Urinary Auto-brewery Syndrome: A Case Report | Annals of Internal Medicine | American College of Physicians
A woman's bladder 'brewed' its own alcohol, tripping drug test | Live Science
https://www.livescience.com/womans-bladder-ferments-alcohol.html
The Automatic Brewery Syndrome (ABS), in which carbohydrates are fermented in the body to brew alcohol, is very rare, but has been reported. However, women made alcohol in the bladder, not in the stomach, and were diagnosed as similar but different from ABS.
A man who brewed beer in the body and had been `` drunken without drinking alcohol '' for many years-gigazine
People with ABS can get drunk just by eating carbohydrates because microorganisms in the gastrointestinal tract turn carbohydrates into alcohol. On the other hand, women did not get drunk because alcohol fermentation occurred in the bladder and alcohol did not flow into the blood from the bladder. Because it is an unnamed disease that is different from ABS, doctors have proposed calling it 'bladder fermentation syndrome' or 'automated urine brewing syndrome.'
The 61-year-old woman visited the University of Pittsburgh Medical Center for cirrhosis and needed to be put on a waiting list for liver transplantation. The visit names a long-mysterious woman's condition.
Before visiting the University of Pittsburgh Medical Center, she visited another hospital, but was unable to get her name on the list because her urine tests were positive for alcohol many times. The doctor in charge told the woman, 'You need to treat alcoholism first.' The University of Pittsburgh Medical Center had a similar diagnosis once, but the woman continued to deny it. Doctors later looked at the woman's test results and noticed that it was 'negative for the alcohol metabolites ethyl glucuronide and ethyl sulfate .' One of these metabolites is usually present in urine for several days after a person drinks. In addition, a test for ethanol was shown to be negative.
Dr. Kenichi Tamama, who was in charge of the woman, also noticed that women had very high blood sugar and yeast levels due to the lack of proper treatment for diabetes. Taken together, doctors hypothesized that microorganisms in the bladder might convert that sugar into alcohol.
To investigate Tamama's hypothesis, the researchers immediately placed a fresh urine sample from a woman on ice and then cultured it at the same temperature as a person's body. Was seen. ' On the other hand, samples cultured at low temperatures or samples added with chemicals that inhibit fermentation did not produce alcohol. Finally, the microorganism responsible for the fermentation in urine was identified as Candida glabrata.
There have been similar reports, but fermentation was found postmortem, or fermentation was only confirmed in test tubes, not in the bladder. Doctors are calling for the importance of recognizing bladder fermentation syndrome, saying that women were able to reconsider liver transplantation after the findings.
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