Marathon is at risk of acute renal failure if not properly taken with water and salt



A study on the water and salt that marathon runners lost during the marathon revealed that runners who challenge long distance running are not only water but also salt, and can be life-threatening due to kidney damage.

The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running | American Society of Nephrology

Marathoners, Take Your Marks… and Fluid and Salt!

The marathon originated from the fact that the Athenian messenger who defeated the Persian hordes in the battle of Marathon in 450 BC, ran to Athenai, about 40 km away from Marathon, and reported good news. In the history book, the messenger Fidi Pidis is said to have taken his breath shortly after the victory, but even in the modern age when the marathon became a sport that penetrated among runners regardless of professional or amateur, 'The most sudden deaths occur among sports.'

A painting depicting a messenger who gave victory to the people of Athens during the marathon battle.



Previous studies found that 82% of runners who completed the marathon had acute renal failure , but the mechanism was not well understood and heat stroke could cause acute renal failure. From this, it was speculated that it might be caused by an increase in body temperature.

Therefore, a research team including Chirag Parikh, a nephrologist at Johns Hopkins University School of Medicine, conducted a monitor survey for participants in a marathon event held in Hartford, Connecticut, USA in 2017. . In the survey, 'blood pressure, heart rate and weight before and after the race' 'three hours of blood and urine tests 24 hours before the start of the marathon, immediately after the end of the marathon, and 24 hours after the end of the marathon' 'body temperature during the marathon' Much more detailed items were tested than in previous studies that only had blood and urine after the marathon, such as “sweat in the marathon collected by the patch”.

At the end of the marathon race, 12 of the 23 runners surveyed had acute renal failure after the marathon. However, since an increase in body temperature was observed in almost all runners, the team concluded that “an increase in body temperature is not a direct cause of acute renal failure”.

Parikh also examined the water and salt that the runner lost, and the runner lost up to 6.81 liters of water and 7.21 g of sodium. Given that the average amount of water in a person with a weight of 70 kg is 42 liters and there is a risk of death if 10% of the water is lost, how about losing about 7 liters of water can strain the body I understand.


Juliano Ferreira

Parikh also found that blood samples from runners with acute renal failure contained 20 times the usual amount of copeptin . Copeptin is a type of peptide that is a compound of amino acids and is a substance produced when antidiuretic hormone is secreted.

As the name suggests, antidiuretic hormone is a hormone that reduces the supply of water to the kidneys and suppresses urine production. The research team said, “In the marathon runner's body, antidiuretic hormone reduces the water supply to the kidneys and prevents urine from being produced, thereby trying to balance the water and salt that are lost rapidly by intense exercise. I guess the mechanism is working. '

by obina Weermeijer

Parikh said, “A lack of water and salt triggers the blood flow to the kidneys and the inflammation of the kidneys is thought to be the cause of acute renal failure,” said the kidney after long distance running He indicated that water and salt supplementation is important to prevent failure.

In the future, the research team intends to develop a method to find the optimal water and salt replenishment method tailored to the individual athlete so that marathon runners can challenge the marathon without being intimidated by the danger of life is.

in Note, Posted by log1l_ks