Magnificent medicine that helps alcohol decomposition and prevents a hangover is likely to appear in the near future

In the next morning that I woke up with a hangover after drinking excessively drinking in tone, "The medicine to cure this bad feeling right now ..." and what will become a feeling of craving for medicines that do not exist right now However, there is the possibility that it will be realized in the near future. A team of scientists at the University of California at Berkeley has confirmed that alcohol's "antidote" using only substances that have already been confirmed to be safe and effective in experiments using mice, We are planning to begin clinical experiments by human subjects in the near future.

A Hepatocyte-Mimicking Antidote for Alcohol Intoxication - Xu - - Advanced Materials - Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201707443

A hangover pill? Tests on drunk mice show promise
https://theconversation.com/a-hangover-pill-tests-on-drunk-mice-show-promise-96188

This research is being promoted by a professor of chemistry and biomolecular engineering and he is also a wine enthusiastYunfeng LuThey are research team of Mr. et al. From his own experience, and from the fact that 8 to 10% of patients who are urgently transported to the hospital in the United States are acute alcohol poisoning, Mr. Lu can enjoy alcohol and save human life without suffering from a hangover I was convinced of the necessity of "alcohol decomposing drug" that leads to things.

Mr. Lu is proceeding with this research with Professor Cheng Ji who specializes in liver diseases at Kec School of Medicine and Duo Xu of a graduate student studying under herself. What Mr. Lu uses is also present in the human liverAlcohol oxidase,Catalase,Aldehyde dehydrogenaseWe aimed to enhance the ability of alcohol decomposition by delivering these from the blood vessel to the liver with three enzymes.

Lu said that the biggest problem was how to deliver these enzymes reliably and efficiently to the liver. Therefore, Mr. Lu has adopted a method of covering each enzyme with a very small capsule with the material already approved by the FDA (Food and Drug Administration) of the United States for medicine, delivering it to the liver with blood flow I will.

Experiments comparing mice that actually administered these enzymes with normal mice said that the difference appeared clearly. In mice given the enzyme, blood alcohol concentration 4 hours after alcohol ingestion is reduced by 45% at the maximum, furthermore it is carcinogenic, and the blood concentration of acetaldehyde which has the effect of causing headache and nausea is also extremely high It has been confirmed that the low state has been maintained. In addition, as soon as the mouse becomes drunk with alcohol, it falls into sleep, but it has also been found that the mouse given the enzyme woke up faster than the mouse not.

ByYu-Chan Chen

Blood alcohol concentration is a factor that is closely related to the intensity of sickness, the lower the concentration, the lower the degree of sickness can be considered. In other words, the fact that the blood alcohol concentration in mice given the enzyme in this study quickly decreased means that the time to be influenced by alcohol was shortened accordingly.

Mechanism of drunk | Successfully with alcohol | CSV activities | Giraffe
http://www.kirin.co.jp/csv/arp/risk/mechanism.html

The degree of sickness depends on the concentration of alcohol in the brain. However, since it is impossible to actually measure the concentration in the brain, instead of determining the degree of sickness by blood alcohol concentration in blood.

The research team is currently at the stage of confirming that these micro capsules do not give unexpected adverse effects to the living body. Once this confirmation is taken, it will be possible to proceed to the clinical experiment using the human body next. The research team is planning that the time will be within one year from May 2018.