A breakthrough treatment that has a great effect on end stage cancer has appeared, but side effects are also intense

BySrgpicker

At the annual meeting of the American Association for the Advancement of Science (AAAS), Dr. Stanley Riddle of Fred Hutchinson's Cancer Research Center plays an important role in immune responseT cellsWe are pleased to announce a new cancer treatment regimen.

Abstract: Engineering T Cells for Safe and Effective Cancer Immunotherapy (2016 AAAS Annual Meeting (February 11-15, 2016))
https://aaas.confex.com/aaas/2016/webprogram/Paper16827.html


Stan Riddell, Fred Hutch cancer immunotherapy innovator, to present at AAAS Annual Meeting | EurekAlert! Science News
http://www.eurekalert.org/pub_releases/2016-02/fhcr-srf020516.php

Treatment saved ~ 90% of terminal cancer patients, but it scary side effects | Ars Technica
http://arstechnica.com/science/2016/02/treatment-saved-90-of-terminal-cancer-patients-but-it-has-scary-side-effects/

The human body has immune mechanism trying to eliminate bacteria and virus infections. Mr. Ridle announced that it can be called "T cell therapy" that T cells that play a role as a commander in this immune mechanism are taken from the body, reprogrammed and returned to the body.

In the past, "fight cancer with an immune response" was a method that was considered promising.

Mr. RiddleAcute lymphoblastic leukemiaT cell therapy was carried out on 29 patients in Japan. Then, 27 of the patients who were in the terminal stage of cancer regained lull. In addition, although there are few cases,Non-Hodgkin's lymphomaYaChronic lymphocytic leukemiaEven patients with effect were seen.

However, strong side effects have also been confirmed, and some patientsCytokine release syndromeSome people suffered inflammation throughout the body and had to enter the intensive care unit. Two of the 29 patients with acute lymphoblastic leukemia mentioned above have died.

The effect seems to be "the doctor has hope", so it is the key to solve the problem of side effects.