A report that a phenomenon that leads to overcoming addiction is found, a user of diet medicine was able to stop drinking and `` habit of biting nails ''



As a result of conducting a clinical trial of a diabetes drug called ``

SGLT2 inhibitor '', it was found that the risk of heart disease and kidney disease in non-diabetic people was suppressed. may result in Patients who used Wegovy , an injection drug used to treat obesity, reported that symptoms of addiction such as drinking, smoking, and impulsive shopping were alleviated.

Could Ozempic Also Be an Anti-addiction Drug? - The Atlantic
https://www.theatlantic.com/health/archive/2023/05/ozempic-addictive-behavior-drinking-smoking/674098/

Wegovy and Ozempic could be anti-addiction drugs as they cure drinking and shopping habits | Daily Mail Online
https://www.dailymail.co.uk/health/article-12111143/Wegovy-Ozempic-anti-addiction-drugs-cure-drinking-shopping-habits.html



Ugobi is an injectable drug containing

semaglutide as an active ingredient that mimics the hormone glucagon-like peptide-1 (GLP-1) , suppressing hunger and slowing down the emptying of the stomach to maintain satiety. It has been approved as an 'obesity treatment agent' in the United States and other countries due to its effect of

Ugobi is so popular that it is estimated that ``1 in 60 American adults have a prescription for obesity drugs such as Ugobi.'' There are reports that the desire for cigarettes has weakened, and bad habits such as nail biting and compulsive shopping have disappeared.

For example, Twitter user Henry Webb said, ``I used two months of Ugobi a month and a half ago and stopped when I reached my goal weight. I drink a lot of alcohol, but my cravings were 'zero' while I was on the drug.This could be a game changer for people struggling with addiction.'



Some have even stopped using Ugobi just because they wanted to drink alcohol. A Twitter user named Jim Melone said, 'My weight loss was minimal and I completely disliked alcohol. I didn't know about this sobriety effect, nor did my doctor. No, I didn't start taking the medicine for this, so I stopped after using it for almost four months and I want to be able to drink socially again.'



There are also voices that habits other than drinking have improved. Victoria Rutledge, who used to be addicted to alcohol and became obsessed with eating and shopping instead of quitting, used Ugobi for weight loss, before she knew it. He said he was slim.

Not only that, I no longer have the desire to shop, so when I went to the supermarket before, I had to put dozens of unnecessary items in my cart. I told him that I was able to take it home with me.

Another patient, Mary Maher, used to have a habit of pinching the skin on her back until it bled, so she couldn't wear white clothes, but two months after using Ugobi, the urge It's gone, and my back is clean. Also, she had a habit of biting her nails, but it seems to have disappeared.



It is speculated that these effects may have been brought about by the ability of Ugobi to mimic GLP-1. A key part of addiction is the brain's

reward pathway , which contains dopamine receptors that bind dopamine released by behaviors such as eating and sex, motivating them to repeat the behavior. However, since GLP-1 reduces the number of dopamine receptors, there is a possibility that even if you do the same action you will not feel pleasure.

This effect has also been reported with other drugs, such as exenatide , which is also used to treat diabetes. One study observed that exenatide-treated mice had reduced dopamine responses to alcohol and reduced cravings for cocaine.

At the University of North Carolina, a clinical trial is being conducted to see if semaglutide can help with abstinence and smoking cessation, and researchers say, ``Many studies showing the positive effects of semaglutide will be published soon.'' I am talking.



While the idea that you can not only lose weight but also quit unhealthy habits sounds like a lot of good news, there are still many unknowns about the long-term effects of semaglutide.

One study suggested that the weight lost with semaglutide rebounded in just a few months, so injections would need to be continued almost forever to maintain its effects. In addition, there are research results that tend to lose more muscle than fat, and reports that people can no longer eat foods they like or have never thought of before.

For example, Stacey Rice, from Georgia, lost so much weight after taking Ozempic, a type 2 diabetes drug containing semaglutide, that she was able to wear the jeans she wore 16 years ago. However, I confessed that I could not drink coffee that I had been drinking since I was a child.

Some doctors also warn of an 'ozempic face' or 'ozempic body,' in which the skin on the face and body sag due to rapid weight loss. From these points, WHO warns that 'Ugobi and Ozempic are not silver bullets.'

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in Science, Posted by log1l_ks