Research results that drinking coffee with milk doubles the anti-inflammatory effect of polyphenols
There are various ways to drink and enjoy coffee, and some people say, 'I always drink it black,' while others say, 'I like to drink it with milk.' An experiment in which polyphenols, an antioxidant contained in coffee, was administered to cells, found that combining polyphenols and proteins doubled the anti-inflammatory effect.
Phenolic Acid–Amino Acid Adducts Exert Distinct Immunomodulatory Effects in Macrophages Compared to Parent Phenolic Acids | Journal of Agricultural and Food Chemistry
Coffee with milk may have an anti-inflammatory effect – University of Copenhagen
https://science.ku.dk/english/press/news/2023/coffee-with-milk-may-have-an-anti-inflammatory-effect/
When pathogens such as bacteria and viruses invade the body, inflammation occurs as a protective response by the immune system. Inflammation can also occur due to the load and trauma caused by exercise, diseases such as rheumatoid arthritis, and oxidative stress on cells caused by active oxygen can also cause inflammation.
Coffee contains caffeic acid and chlorogenic acid , which are types of polyphenols, and past studies have demonstrated that it exhibits antioxidant and anti-inflammatory effects. I wasn't sure about the effects of doing so.
Therefore, a research team at the University of Copenhagen, Denmark first generated artificial inflammation in mouse immune cells and then divided them into groups. An experiment was conducted in which polyphenol reacted with a certain
They found that cells given a combination of polyphenols and cysteine produced half as many factors associated with inflammation as those treated with polyphenols alone. This means that the combination of polyphenols and amino acids doubles the anti-inflammatory effect.
Marianne Nissen Lund, who led the research team, said, ``This study showed that when polyphenols reacted with amino acids, the anti-inflammatory action of immune cells was enhanced. In the future, we would like to proceed with investigations in animals first, and then raise research funds to verify the effects in humans.”
Previous studies by the research team have demonstrated that polyphenols bind to proteins in meat products, milk and beer, and another study also showed that polyphenols react with proteins in coffee with milk. I verified whether it is, and concluded that 'a reaction between polyphenols and proteins occurs in coffee drinks containing milk.'
Also, since this reaction occurs very quickly, it is said that it occurs in every food combination studied so far. In other words, it is highly likely that the same thing is happening with the combination of meat dishes and polyphenol-rich vegetables, and the smoothies that add milk or yogurt to fruit.
Based on these findings, Lund said, ``Since humans cannot absorb polyphenols very well, many researchers are looking for ways to incorporate polyphenols into the structure of proteins to increase absorption. This study also found that it has the benefit of enhancing the anti-inflammatory effects of polyphenols.'
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