It is shown that asthma therapeutics may be a specific drug for dementia
It has been suggested that an asthma drug approved by the US Food and Drug Administration (FDA) may have the effect of revealing previously hidden knowledge. If this drug proves to be effective, it is expected to become a specific drug for dementia and Alzheimer's disease.
Recovering object-location memories after sleep deprivation-induced amnesia: Current Biology
'Magic' Drug Restores Lost Memories and Unleashes Hidden Knowledge - The Debrief
A research team led by neuroscientist Robert Jabekes of the University of Groningen focused on learning during sleep deprivation and the difficulty of retrieving that knowledge, and found that lost memories and hidden secrets held in the brain are important. In order to evoke the learned knowledge, we conducted an experiment using mice.
The research team of Mr. Jabequez et al. Genetically manipulated mouse hippocampal neurons to produce proteins that respond to light. This protein is activated by exposure to light. Moreover, protein activation enables mice to recall learned memories.
Next, genetically engineered mice were tested to learn the locations of multiple objects and recall their locations. Also, at that time, the research team intentionally made half of the mice sleep deprived. Since the test to recall the position of the object by the mouse greatly depends on the function of the hippocampus, it is useful for the test to restore the lost memory.
A few days after learning the object's location, one of the objects was moved and tested again. I forgot the position of the object.
roflumilast , which is known to activate nerve cells in the brain. By the way, an effect similar to activation by light irradiation appeared in mice.
But when the researchers activated the protein in sleep-deprived mice with light and tested it again, these mice accurately recalled the original location of the object. This result indicates that the learned information was preserved in the brain even during sleep deprivation. However, in order to retrieve the information stored in the brain, stimulation is required.
Unfortunately, genetic manipulation methods used in mice are difficult to apply to humans from an ethical and health standpoint. Therefore, in order to discover a method to retrieve information stored in the brain without harming human health, the research team led by Jabequez administered
Roflumilast is an FDA-approved treatment for asthma and is a widely prescribed and safe drug. By administering roflumilast to humans, it is expected to have the same effect of recalling memories as mice.
The biggest achievement of this discovery by Jabequez and his team is that people with dementia, Alzheimer's disease, or other forms of memory loss can regain some of the life they've lost due to their illness. It is said that there is a possibility that it can be helped by
'It may be possible to administer the asthma drug roflumilast to stimulate and recall memories in people with dementia and early-onset Alzheimer's disease,' Jabequez said. We may be able to reactivate certain memories so that we can remember those memories forever.' 'We hope that this research will lead to the development of medicines to restore lost memories. ' said.