Experimental results will be announced that the synthetic coloring agent `` Red No. 40 (Arura Red AC) '' is related to colitis
Experiments with mice have revealed that artificial coloring '
Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice | Nature Communications
https://doi.org/10.1038/s41467-022-35309-y
Allura Red AC (commonly known as Red No. 40) is used as a coloring application for industrial products and as a food additive. In 2007, the British Food Standards Agency recommended that manufacturers self-regulate, saying that children with some disabilities need to be careful about inoculating Red No. 40. On the other hand, the European Food Safety Authority (EFSA) says that the effects of Red 40 and other food additives are unknown, and opinions are divided on how to handle food. Red No. 40 can also be purchased on Amazon as food coloring.
Amazon | Food coloring red No. 40 food coloring 500g |
Previous studies have shown that Red No. 40 promotes oxidative stress and inflammation in the liver and kidneys of mice. On the other hand, there was not much research on the relationship between Red No. 40 and intestinal inflammation. A new paper published in Nature Communications observes that the continuous addition of Red No. 40 to the diet of mice increases the risk of developing colitis.
In the experiment, the effect of continuous inoculation was observed by continuously feeding mice with food containing Red No. 40, which is the same amount as the general content in human food, for a long period of time. increase. As a result, the researchers show that several of the mice fed Red 40-containing diets for 14 weeks developed mild intestinal inflammation. In addition, it was found that mice with inflammatory bowel disease were more likely to develop colitis by taking Red No. 40 for a long period of time. On the other hand, when a diet ingesting Red No. 40 once a week instead of every day was continued for 12 weeks, there was almost no effect on colitis.
In addition, control experiments have shown that ingesting Red No. 40 in childhood increases the likelihood of developing colitis later in life, and that serotonin increases the severity of intestinal inflammation.
Researchers warned that the artificial coloring contained in the diet is a ``risk factor,'' but the effect on mice was confirmed. It is pointed out that it is a situation that is unlikely to occur with daily meals. In addition, the effect of Red No. 40 on intestinal inflammation was confirmed in experiments with mice, and it is unknown whether the same effect is seen in humans. It will not only encourage scrutiny of its use in humans, but also raise public awareness to prevent adverse health effects, ”he said, indicating the importance of further research.
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