Signs of aging appear when young mice are transfused with blood from old mice
Humans have long sought immortality and rejuvenation in various ways, and in recent years, experiments using mice have shown that ``blood transfusion of young mice can provide benefits such as
Systemic induction of senescence in young mice after single heterochronic blood exchange | Nature Metabolism
https://doi.org/10.1038/s42255-022-00609-6
Scientists Gave Young Mice The Blood of Old Mice.
https://www.sciencealert.com/scientists-gave-young-mice-the-blood-of-old-mice-then-things-got-weird
Aging: Transfusing blood from an old mouse to a younger mouse causes cellular aging | New Scientist
https://www.newscientist.com/article/2332402-transfusing-blood-from-an-old-mouse-to-a-younger-mouse-causes-ageing/
Young mice transfused with blood from old mice became fatigued faster and ran shorter distances
https://medicalxpress.com/news/2022-08-young-mice-transfused-blood-fatigued.html
Previous studies have reported that ``injecting blood from young mice into old mice rejuvenates organs, tissues, and brain functions.'' A new research team in the United States and South Korea conducted an experiment to ``inject the blood of an old mouse into a young mouse'' on the contrary.
The research team prepared a young mouse 3 months old and an old mouse 22 to 24 months old, and transfused the blood of the old mouse to the young mouse for a week. In addition, mice that received blood transfusion from the same young mice were also prepared as a control group, and their physical strength, muscle strength, biomarkers, etc. were compared.
As a result of the experiment, it was confirmed that the mice that received blood transfusion from the old mice were exhausted earlier than the control group and could run only a short distance when running on the treadmill, and were inferior to the control group in muscle strength tests. I was. In addition, biomarkers of kidney and liver damage were also increased in mice transfused with blood from aged mice, the researchers report.
In this study, when old mice were transfused with blood from young mice, the aged mice showed improvement in obesity and fibrosis, decreased fatigue, and increased muscle endurance.
In addition, the research team also conducted experiments to place human kidney cells in plasma collected from elderly humans aged 60 to 70 years. As a result, within 6 days from the start of the experiment, kidney cells began to release multiple biomarkers indicating aging. These biomarkers were not found when kidney cells were placed in plasma collected from humans aged 20-30.
Based on the results of this experiment, the research team believes that a substance called senescence-associated secretory phenotype (SASP) secreted from senescent cells that have stopped cell division acts on young mouse cells and accelerates aging. From this point of view, working with various factors including SASP may lead to the development of new therapeutic strategies to achieve longevity.
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