Successful 'experiment to rejuvenate mouse cells' shows that kidney and skin functions have been rejuvenated
Aging is inevitable for animals, including humans, but many scientists 'rejuvenate the body' because of the increased risk of bone brittleness, muscle weakness, and various other illnesses with age. I have been studying 'how to make it'. Research teams such as the
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging
https://www.nature.com/articles/s43587-022-00183-2
Cellular rejuvenation therapy safely reverses signs of aging in mice --Salk Institute for Biological Studies
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Cellular'Rejuvenation' Experiment in Mice Reverses Signs of Aging, Scientists Say
https://www.sciencealert.com/making-cells-revert-to-a-younger-state-safely-reversed-signs-of-aging-in-mice
Mr. Yamanaka, who won the 2012 Nobel Prize in Physiology or Medicine, is known for developing induced pluripotent stem cells (iPS cells) that can differentiate into many cells and also have self-renewal ability. iPS cells can be produced by introducing four types of genes ( Oct3 / 4 , Sox2 , Klf4 , c-Myc ) into somatic cells, and these four genes are collectively called ' Yamanaka factor '.
Most of the research on iPS cells introduces genes into cells collected from animals, but the team at Salk Institute for Biological Studies has been researching methods to rejuvenate aged animals by introducing Yamanaka factor into living animals. I did. In 2016, we conducted an experiment to introduce the Yamanaka factor into mice with progeria and succeeded in extending the lifespan of individuals suffering from progeria.
By applying iPS cell production technology, it is possible to rewind and rejuvenate 'aging' and succeed in prolonging the life of progeria mice --GIGAZINE
by Maurits Verbiest
The research team 'regularly treats mice 15 to 22 months old (equivalent to 50 to 70 years old in humans)' and '12 years old' to confirm the effect of long-term introduction of Yamanaka factor into cells in the body. It is divided into 3 groups: 'Regularly treat mice of ~ 22 months (equivalent to 35 to 70 years old in humans)' and 'Treat mice 25 months old (equivalent to about 80 years of age in humans) for 1 month'. I did an experiment.
Experiments have shown that tissues such as kidneys and skin show signs of rejuvenation in mice that have been introduced with Yamanaka factor over a long period of time without increasing cancer or other health risks. Specifically, treated mice had a higher 'ability to proliferate skin cells when injured' than untreated mice, were less likely to leave scars, and had normal blood metabolic molecules. It was not accompanied by the changes seen in aged mice. In addition, the research team reports that decreased gene expression that causes inflammation, cell death, and stress responses, and DNA methylation patterns that are indicators of aging have also been rewound against age.
The researchers showed no signs of rejuvenation in mice treated for only one month, and no clear effect of rejuvenation was seen when analyzing mice undergoing long-term treatment. , Claims that treatment with Yamanaka factor has been suggested to rejuvenate cells rather than simply suspending aging. However, more research is needed on this point.
'What we really wanted to establish was that long-term use of this approach was safe. Indeed, health in these animals,' said Pradeep Reddy, co-author of the paper at the Salk Institute for Biological Studies. No adverse effects were found on behavior or weight. '
Juan Carlos Izpisua Belmonte of the Salk Institute for Biological Studies, who was the senior author of the paper, said, 'We are enthusiastic that this approach can be used for life because it slows the aging of common animals. It was safe and effective. '' In addition to tackling age-related diseases, this approach improves cell function and resilience in different diseases such as neurodegenerative diseases, and restores tissue and body health. It is possible that we will provide new tools to the medical community. '
The results of this study are intended only for mice, and it is thought that it will take a long time to apply to humans. 'We want to make older cells elastic and functional, at least in mice, so that they are ultimately more resistant to stress, injury and disease.' , Showing that there is a way to achieve that. '
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