Research result that goose bumps are the true reason to grow hair, there is a possibility that light may be applied to bald treatment



Recent research has revealed that

goose bumps that can be felt on the skin when you are moved by listening to music or when you are horrified or chilled have a mechanism or role that was unknown until now.

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells: Cell
https://www.cell.com/cell/fulltext/S0092-8674(20)30808-4

The hair-raising reason for goosebumps is revealed – Harvard Gazette
https://news.harvard.edu/gazette/story/2020/07/the-hair-raising-reason-for-goosebumps-is-revealed/

Science May Have Finally Explained The Reason Why We Still Get Goosebumps
https://www.sciencealert.com/science-may-have-finally-explained-the-reason-why-we-get-goosebumps

NTU researchers seek clues on hair loss in goosebump phenomenon-Focus Taiwan
https://focustaiwan.tw/sci-tech/202008060013

'Skin is a truly attractive system. The skin that separates our body from the outside world has stem cells surrounded by a wide variety of cell types,' says a Harvard biologist. Mr. Ya-Chieh Hsu. Hsu et al.'s research team used a high-resolution electron microscope to observe the hair follicles of the mouse in order to investigate in detail the mechanism by which the skin adapts to changes in temperature outside the body and protects the body.

The following is a photomicrograph of a mouse hair follicle taken by Hsu et al. The green color is the sympathetic nerve, which is related to the mechanism of goose bumps, and the purple part is the pili muscle, which has the function of making the hair upside down.



Previous studies have shown that 'the condition where goose bumps are the state where the piliary muscles stimulated by nerves raise the skin is the true identity of goose bumps.' We also found that 'stem cells,' which have both the ability to proliferate and the ability to differentiate into other types of cells, are also involved in the mechanism of goose bumps.

The figure below illustrates the mechanism. I feel the cold and the goose bumps on the right change from the normal state on the left to the contraction of the pink pilus muscle. This study further found that when goosebumps develop, the green sympathetic nerve releases neurotransmitters that act on blue hair follicle stem cells, which activates hair follicle stem cells and promotes hair growth. It was



Hsu said, 'It was very surprising to see that neurons and stem cells interact in synaptic- like structures by observing them at the ultrastructural level, because nerve cells can interact with other neurons. It's common to connect with excitable cells that have synapses like muscles, and it's very rare to target cells like hair follicle stem cells.'

Researchers added to the conventional theory that 'goosebumps were formed in the days when humans still had hair, to make hair upright and create a layer of air to overcome the cold on the spot.' I think that the long-term strategy of “promoting hair growth to increase the amount of hair and cope with the future cold weather” is related to the mechanism of getting goose bumps.

In addition, when the research team conducted an experiment to remove the pili muscle from the hair follicles of mice, it resulted in the loss of the connection between the sympathetic nerve and the stem cells. Since it is known that the pili muscles in hair of alopecia males also have a very weak reaction, Professor Sung-jan Lin of the co-author of the article, National Taiwan University, said that the mechanism of alopecia occurs. , I believe that there is a close relationship between the functions of the pili and sympathetic nerves.

'This study found that the hair follicle stem cells are activated by receiving signals from the sympathetic nerve via the ADRB2 receptor ,' said Lin. He pointed out that the development of a drug that makes the alopecia effective will enable effective treatment of alopecia.

in Science, Posted by log1l_ks