Researchers discovered 8000 ways to improve efficacy with 'antibiotic cocktail' to counter the 'super bug' where antibiotics do not work

by JeongGuHyeok

When multiple medicines are combined, the effects are usually canceled out between medicines and the effect becomes small. However, biologists at the University of California, Los Angeles have discovered combinations of antibiotics that exert high effects against harmful bacteria. This means that 4 to 5 antibiotics are combined at the same time, and there are about 8000 combinations to be present. Although research is still in the early stages, there is a possibility that it will be used against bacteria that antibiotics will no longer work in the future.

8,000 new antibiotic combinations are surprisingly effective, UCLA biologists report | UCLA
http://newsroom.ucla.edu/releases/8000-combinations-antibiotics-surprisingly-effective

Scientists Just Found 8,000 New Drug Cocktails For Fighting Antibiotic Resistance
https://www.sciencealert.com/8000-new-drug-combinations-could-fight-antibiotic-resistance

Pamela Yeh who studied, "We should not limit the antibiotics we take to one or two antibiotics, but by combining multiple antibiotics, we will have higher efficacy than existing antibiotics I can do it. "

To see the efficacy against Escherichia coli, Yeh Mr. and others began studying from a method using eight antibiotics and confirmed the effectiveness of a method combining four to five kinds of antibiotics. It seems that we finally tried a combination of 12,878 combinations, while adjusting the dosage.

by stevepb

According to researchers, 1676 combinations are combined in the method combining four antibiotics, and 6443 combinations with the combination of five antibiotics show higher effect than expected. Meanwhile, there were 2331 combinations of 4 antibiotics and 5199 combinations of 5 antibiotics, which were less effective than researchers' expectations.

"I was amazed at the fact that there are so many combinations that will increase the effect by increasing the number of antibiotics." "People seem to know how drug combinations work and I do not know," Mr. Van Savage who went was talking.

by Myriams-Fotos

Because antibiotic approaches to approach bacteria differ depending on things, it is the background that multiple effects can be made possible by multiple combinations. "There are things that attack cell walls, others attack DNA from the inside, like when attacking fortresses and castles," Savage said.

However, it should be noted that this time it was an experiment conducted only in Escherichia coli and in a limited environment of "laboratory". You also have to be careful that you need careful systematic selection of medications to treat a specific condition. Furthermore, in the 2013 study , it has also been shown that using multiple antibiotics increases bacterial aggression.

The dangers of superbugs that do not have antibiotics are screamed globally, and the British government suggests the possibility that the epidemic diseases caused by resistant bacteria will spread and that a future will come when one person dies in three seconds.

Shocking report that Super Bacteria may kill one person every 3 seconds in 2050 - GIGAZINE

Under these circumstances, in order to prevent future pandemics, discovery and development of new countermeasures against bacteria are required. Michael Kurilla of the National Institutes of Health says, "The presence of resistant bacteria combines existing antibiotics that are diminishing in effectiveness because they may reverse health care in times before antibiotics are developed Wise ways are welcomed. "