A secret secretly hidden in genes of Shawn Bradley who is flying out amongst NBA players

The average height of a professional basketball player belonging to NBA is said to be 203 cm, and it is the world where only a handful of selected people with a blessed physique can participate. Among the NBA's, the secret of tremendous high stature has been revealed from the genome of Shawn Bradley, a famous long-time player known for its height,

Common DNA Variants Accurately Rank an Individual of Extreme Height
https://www.hindawi.com/journals/ijg/2018/5121540/

BYU genetic researchers solve a giant mystery: How Shawn Bradley got to be so tall
https://news.byu.edu/news/byu-genetic-researchers-solve-giant-mystery-how-shawn-bradley-got-be-so-tall

Dr. John Cowe, a biologist at Brigham Young University, faced several years ago with the former NBA player Sean Bradley in the aircraft's first class. Bradley's play, which is known for its long life among NBA, can be confirmed in the following movie.

Shawn Bradley Top 10 Plays of Career Highlights - YouTube


Bradley's height is 229 centimeters, it is said that it is the height of the tall located in the 99.99999 percentile among the human race. Bradley outside the standard seems to have been forced to have a cramped attitude that even the first-class spacious seat shrugged his upper body and shrugged his legs.

Dr. Cowe who is also a geneticist talked to Bradley and told that "I am interested in your high height and genes." Bradley has a high physical ability to play a leading role in NBA, the body is health itself, high body height is not caused by genetic diseases called so-called gigantism, but a special gene that causes high stature Dr. Cowe thought that Bradley had it.

Bradley, who felt it interesting to find out what Dr. Cowwe would find, agreed to be a sample of the research and research to search for genes responsible for high tallies began.

Dr. Cowwe's research team began by classifying the "genetic variations affecting high height" listed by the GIANT consortium . And I sorted out those that seemed to be influential and selected the candidate genetic variation of 2910. In addition, we sorted and sorted genes affecting height by using genome datasets for 1020 people. After that, we decided to compare 3 billion base pairs obtained from Bradley's genome with high stature genes.

Dr. Cowe thought that Bradley would have a special mutation in the gene affecting the known high height, but mutation was not confirmed. Instead he got from the test results that it was the fact that "Bradley has almost all generic genes that are likely to affect high height". Dr. Cowwe says, "If you are outrageous and tall, you may possibly have all genetic traits related to high stature.Sean Bradley's DNA has all the high stature genes It defines the limit of the possibility of having it. "

Genetically, this research is genetically based on the hypothesis that many loci affecting small traits are related to traits, weighting individual polymorphisms from the analysis result of the whole genome, It is meaningful that it discovered that "Polygenic score" conducting risk analysis was found to be successful in predicting the extreme phenotype "human being extraordinarily tall".

In addition, Bradley knows that it has as many as 198 "high height genes" than general people, and this research found that it belongs to "the tallest rank". However, it seems that he could not infer accurately the height from the number of high stature genes.