Experiments in mice found that daily ingestion of cannabis ingredients has the effect of undoing brain aging and mental degeneration

ByJurassic Blueberries

Experiments using mice have highlighted the possibility of preventing brain aging accompanying aging by routinely ingesting active ingredients contained in cannabis. However, it seems that it is unclear how much health of the mouse can be secured from the amount of ingredients administered to obtain the effect.

Daily dose of cannabis extractable reverse brain's decline in old age, study suggests | Science | The Guardian
https://www.theguardian.com/science/2017/may/08/daily-dose-of-cannabis-extract-could-reverse-brains-decline-in-old-age-study-suggests-thc

Mice's aging brains reset to youthful state by cannabinoid | Ars Technica
https://arstechnica.com/science/2017/05/in-mice-marijuanas-active-ingredient-reverses-mental-decline-of-age/

In a study by a joint research team between Germany and Israel, the active ingredient "THC (Tetrahydrocannabinol) Was given for 4 weeks. These mice are age-matched generations of "young mice, middle-aged and older mice, and old mice", and what kind of change occurs in each brain, mental state change and gene activity The level is being investigated.

THC is the basis for producing the euphoric effect of cannabis, it is provided in the animal's bodyCannabinoid receptorThis mechanism is created by combining it with other parts. Previous studies have shown that the function of this cannabinoid receptor decreases with age, and the research team thought that it is related to the deterioration of spiritual work associated with age.

Therefore, the research team gave THC to the above three types of mice and observed change in learning ability and memory ability. As a result, it was said that aging did not affect the effects of aging in all ages, and in both cases, the ability was found to be equivalent to the mouse of 2 months old. In addition, it is said that the same "rejuvenation effect" is confirmed for the level of gene activity.

ByDeviat_ed

On the other hand, however, it was also found that in the brains of mice given THC two months after birth, the state of gene activity was in the same state as the old mice not given THC . For this mysterious result, the research team says "further verification is desirable".

In this way, although it is an experiment with a mouse that can also take "rejuvenation", it does not seem to be without drawbacks. In this study, 3 milligrams of active ingredient per kg of body weight is given to mice, and if converted per hour, it is estimated that, per kg body weight125 microgram per hourIt will be the number. In the case of humans, per 2 kg of body weight which is twice this value250 microgram per hourIngesting the active ingredient of the same level causes a clear adverse effect on the driving of the car, that is, "I am lyingBecause it means that it is a state, it may be said that whether normal seniority can be lost even if aging is halted.

The research team is planning to conduct studies that humans participate in the latter half of 2017. Papers by the research team can be viewed from the following links.

A chronic low dose of [Delta] 9-tetrahydrocannabinol (THC) restores cognitive function in old mice: Nature Medicine: Nature Research
https://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4311.html