A secret part that can keep on living longer than usual is revealed


Some of the rats inhabiting the Middle Eastern region have thirty years of a long lifespan. It is known that the secret of longevity is "low incidence of cancer", but recent research has found that there is a reason attributable to the function of the cell.

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It is a type of mouse living in the groundMegane Rat(Blind mice) live in the same Middle EastHadaka deerAlong with 30 years as a longevity owner is known. Considering that the life expectancy of other rats is about two years, it can be said that this is a tremendous longevity. The discovery by a research team at the University of Rochester in the UK has revealed that meclimens kill bad cells, which are the source of cancer cells, by secreting a large amount of "Interferon β", a protein type Another research team at the University of Rochester found that there is another longevity mechanism other than that. The process of unique protein synthesis in the mouse,I am delaying aging itselfIt is said.

Three types of RNA "mRMA" "tRNA" "rRNA" are involved in the synthesis of proteins in the body. First of allMRNA(Messenger RNA) copies the DNA information that stores the genetic information of the organism. Next, it is "Carriers"TRNA(Transfer RNA) carries the mRNA that copied the information to the ribosome that is the "protein factory" and finally constitutes the ribosomeRRNA(Ribosomal RNA), the information of mRNA is copied and the protein is synthesized. When failure occurs at the stage of copying mRNA information performed in this ribosome, the synthesized proteinDefective proteinIt will become impossible to fulfill the original role. Defective proteins that have lost their function are accumulated in the body, the reduction of collagen prevents the skin's tightness and the weaker digestive enzymes become unable to digest food more efficiently than beforeAgingIt will cause it.

ByEthan Hein

A research team focused on the relationship between the longevity of the Meshimbushi and the defect protein studied the protein synthesis mechanism in detail. The rRNA contained in the ribosome synthesizing proteins can be further classified into 4, but only the Meclen is one of them28SThere is a special mutation in what is called, and we discovered that there are two 28S in Meclane that normally contain one for each ribosome.

Furthermore, in order to investigate the influence of this feature on the protein synthesis process, the research team conducted gene manipulation on two kinds of the mouse and usual experimental mouse, and when the defective protein is synthesized in the body, the cell emits light I made an observation so as to do. If the synthesized protein is normal, nothing happens and only the mouse with the problem will emit light. As a result, it was confirmed that the cells of Mescarrot scarcely emitted light, was "darker" than other rats, and that the synthesis amount of defective proteins was lower than the other rats. It seems that the failure rate of protein synthesis was 4 to 10 times lower than that of other rats.

ByDcb aok

At this stage it is premature to conclude that 28S is realizing longevity because no specific evidence has been found that 28S is involved in raising the accuracy of protein synthesis. However, this is regarded as an interesting research result showing that the secret of the longevity of Megumi rats has another reason other than low cancer incidence.

Whether or not this mechanism applies to humans has not been clarified yet, it may be a hint of healthy longevity.

in Science, Posted by darkhorse_log