A new way to treat cancer in the US is patented

In the United States announced that some groups acquired patents on cancer treatment. The object seems to be a compound of "sugar" and "short chain fatty acid". It is a wonder that it will be possible to lower the proliferation rate of cancer cells and to change the cancer cells themselves into normal cells.

this isDecember issue of "Chemistry & amp; Biology"According to Jones Hopkins University, who was involved in this research, although the animal experiment and the influence on the human body have not been confirmed yet at the stage, it is said that there is no difference that it is promising in the future.

It is quite a special story as to what it is, so it is unknown, but let's take a moment. The cancer treatment may develop in a slightly different direction from now ... ....
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According to this, there have been few researchers paying attention to what the so-called sugar exerts on cancer cells, but actually, in the 1980's already over 20 years ago, short-chain fatty acids, that is, "butyric acid Salt "decreases the spreading rate of cancer cells, the fact that it is possible to restore cancer cells to normal cells, in particular in the digestive system, by the synergistic effect with dietary fiber It seems that it was known. I think that this fact is surprising because it is just an ear, but when I looked it up, I could certainly find several pages that write such things.

Bettarian has little cancer

The eighth group must contain butyrate. Butyrate is a simple fatty acid, which is a bifidobacterium for human health in bacteria living in the large intestine, is produced in the large intestine by butyrate. Bifidobacteria break down compounds such as inulin or oligoflactose. Oligo fructose is also contained in artemis chalk (ginseng) other foods. Butyrate has the ability to generate colon differentiation abnormality and has an important function of stopping the progression of colon cancer. Although it is an interesting fact, at least for experimental animals, water soluble dietary fiber is effective to prevent breast cancer. Butyrate or similar substances have anticancer effects at many other sites in the body.

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Evidence shows that dietary fibers are playing a preventive role in reducing the incidence of colorectal cancer. Most animal experiments and epidemiological studies show that dietary fiber has a preventive effect on colon cancer. [20] The term fiber refers to a complex mixture such as insoluble fiber typified by wheat bran and cellulose, and soluble fiber such as dried beans. Due to fiber ingestion, carcinogenesis may be altered by various potential mechanisms within the large intestine. [62] [63] [64] These mechanisms include binding of fibers to bile acids, increased fecal water content and resulting dilution of carcinogens, shortening of transit time of colonic contents (obvious factors is not). By using fiber as a material for fermentation, the amount of intestinal bacteria increases and the production of short chain fatty acids typified by butyrate is promoted. [64] Butyrate has antitumor activity in vitro and is considered as an important energy source for colonic epithelial cells. [65] [66] As a result of a meta-analysis on 13 case-control studies conducted in nine countries, it was revealed that the intake of high fiber foods was inversely correlated with the onset of both colon and rectum cancers It was made.

In other words, if somehow migrate or permeate butyrate into cancer cells, it may be possible to repair the cancer cells into normal cells, or it may be possible to prevent cancer cell formation It is that.

This time, the US patent raises this short chain fatty acid "butyrate" to the level to use it as a general medicine to improve it. However, at first it failed, it seems that side effects have become intense. But as a result of further research, we discovered that harmless sugar molecules, glucose, can carry butyrate into cells.

The actual identity of what is simply called "sugar" is "N-acetyl-D-mannosamine" or "acetyl mannosamine (ManNAc)". Is it to combine this with butyrate?

Compounds in which acetyl mannosamine and butyrate are bound easily penetrate into the cell surface and have the characteristic that they are degraded by enzymes in cells. This means that acetylmannosamine is processed into a substance that plays an important role in cancer research called sialic acid, and it is possible to stop the activity by acting on genes responsible for the growth of cancer cells.

In short, this is the key to trigger the phenomenon of apoptosis and cell suicide in infinitely proliferating cancer cells, in fact it has succeeded in slowing down the growth rate of cancer cells in the experimental environment or killing the cancer cells themselves It is said that it is. The interesting thing is that even if this acetyl mannosamine and butyrate are not bound to each other and administered separately, no effect is observed, and only when administered after cancer cells will act on cancer cells. As it is still in the early stages of the study, it is unknown that it is not clear, but probably the binding itself is restoring the mechanism of cancer cell development, which is an abnormal action of the gene, to a gene that should be normal. It seems to be guessing.

In the near future, it is expected that side effects are extremely few and it will become a drastic treatment.