Research reveals cause and treatment of designated intractable disease 'systemic lupus erythematosus'
A study has been published in the scientific journal Nature that has discovered a molecular defect that promotes the pathological immune response in
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus | Nature
https://www.nature.com/articles/s41586-024-07627-2
Scientists Discover a Cause of Lupus and a Possible Way to Reverse It - News Center
https://news.feinberg.northwestern.edu/2024/07/10/scientists-discover-a-cause-of-lupus-and-a-possible-way-to-reverse-it/
The research was conducted by Dr. Choi Jae-hyuk of the Northwestern University Feinberg School of Medicine.
SLE is an autoimmune disease that can lead to life-threatening skin, brain, kidney and lung diseases, and affects 1.5 million people in the United States, Dr. Choi said.
The team discovered a molecule called the aryl hydrocarbon receptor (AHR), which plays a role in regulating cellular responses to environmental pollutants, bacteria, and metabolic products. In SLE patients, the pathway controlled by the AHR is underactivated, leading to overactivity of peripheral helper T cells, which promote the production of disease-causing autoantibodies.
Dr. Choi and his colleagues suggest that reprogramming the cells that cause SLE into so-called Th22 cells may help the body recover from the damage caused by autoimmune diseases.
Dr. Choi and his research team, including Dr. Deepak Rao, aim to expand their efforts to develop new treatments for SLE patients by exploring ways to safely and effectively deliver AHR-activating molecules to people.
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