``Artificial sweeteners may not be safe'' is pointed out in a study investigating the effect on the intestinal flora
There are various types of artificial sweeteners that give a sweet taste, such as acesulfame potassium (acesulfame K), saccharin, and sucralose. A randomized controlled trial in healthy adults suggested that some artificial sweeteners may affect the intestinal flora, also called intestinal flora.
Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance - ScienceDirect
Sugar Substitutes Surprise | Science | AAAS
https://www.science.org/content/blog-post/sugar-substitutes-surprise
Artificial sweeteners such as saccharin, cyclamate and non-metabolized sucralose, which are regulated in some regions, have all been questioned about their safety, said organic chemist Derek Lowe. In particular, experiments with rats have pointed out that Cyclo is suspected to be carcinogenic, and many countries have announced that its use is prohibited. It was later pointed out that this experiment was not reproducible, but Japan and others continue to ban its use.
'I can't tell you how many times I've come across claims that aspartame, sucralose, etc. are causing epidemics of cancer, liver failure, epilepsy, autism, and all sorts of other bad things imaginable,' Rowe said. There is no real evidence for it, and there is a lot of evidence to the contrary,' but introduces one study published in September 2022.
In a study conducted by Josam Suez of the Weizmann Institute of Science in Israel and colleagues, 120 people were divided into groups and given aspartame, sucralose, saccharin, or artificial sweeteners such as stevia mixed with glucose. We prepared a group, a group that was given only glucose, and a group that was given no sweetener at all.
As a result of a 14-day continuous intake of the above substances, significant changes in the intestinal flora were observed in the sweetener group, and in the saccharin and sucralose groups. It was found to be correlated with blood sugar response.
Regarding the results of this study that artificial sweeteners change the intestinal flora, Lowe said, ``All four sweeteners significantly changed the intestinal flora, and it was difficult to predict the effects. Research suggests that commonly consumed sweeteners may not be 'physiologically inert in humans' as previously thought.'
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