Successful experiment in making human brain cells learn how to play games
Cortical Labs, which aims to develop machines with biological intelligence by fusing brain cells from humans and mice into computing devices, and multiple universities including Monash University, the University of Melbourne and University College London A team of researchers used a biological neural network (BNN) created from 800,000 stem cell-derived human cells and embryonic mouse cells to play the arcade game
In vitro neurons learn and exhibit sentience when embodied in a simulated game-world: Neuron
https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6
Scientists Taught Brain Cells in a Dish to Play Video Games and It's Pretty Wild
https://www.vice.com/en/article/pkgm8g/scientists-taught-brain-cells-in-a-dish-to-play-video-games-and-its-pretty-wild
Scientists teach brain cells to play video game Pong | Neuroscience | The Guardian
https://www.theguardian.com/australia-news/2022/oct/13/scientists-teach-brain-cells-to-play-virtual-pong
Using DishBrain, which is equipped with a multi-electrode array that can sense cell activity and stimulate cells, the research team used BNN to provide feedback on whether or not the pong-controlled 'paddle' was able to hit the ball back. I gave it to Within five minutes of starting feedback using DishBrain, the cells started learning how to play Pong.
The longer the learning time, the longer the cells were able to perform a longer rally. In addition, human-derived cells were able to rally for longer periods of time than mouse-derived cells. You can check out how cells actually play Pong in the video below.
Watch brain cells in a dish learn to play Pong in real time [1/2] - YouTube
Dr. Brett Kagan, lead author of the study and chief scientific officer at biotech startup Cortical Labs, said, I chose Pon because there was at least one.'
In addition to Pong, the research team had the cells play 486 different games, and analyzed the ``response'' or ``lack of response'' to various stimuli. For example, some games provide feedback by ``giving information'' or ``deleting information'' to cells. The research team is training gameplay without feedback, but in this case it seems that the cells were unable to learn ``how their actions affected the environment.''
The research team plans to examine how cells function when they are drunk or administered drugs, and are considering using DishBrain to analyze diseases such as epilepsy and dementia in more detail. It seems that they are doing so.
Dr. Kagan said that by showing that neurons change their behavior based on feedback, they were able to demonstrate ``something akin to intelligence.''
'This is a new way to think about what a neuron is,' Dr. Kagan said. 'Neurons are not computers, but they process information and respond intelligently with incredible speed, low power consumption, and flexibility. I think we were able to show that this is a small biological device that can do this.'
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