Research results show that 'laughing gas' may be useful in treating depression

Some people with depression do not respond to antidepressants. However, research results have been published showing that the use of low-concentration

Low doses of'laughing gas' could be fast, effective treatment for severe depression
https://medicalxpress.com/news/2021-06-doses-gas-fast-effective-treatment.html

Laughing gas may treat depression, small study suggests | Live Science
https://www.livescience.com/laughing-gas-treats-depression.html

The study was conducted by the University of Chicago School of Medicine and the University of Washington and was published in Science Translational Medicine.

In 2015, Peter Nagael and colleagues at the University of Chicago published a previous study that 'nitrous oxide gas improves depressive symptoms.' The content says, 'Inhalation of 50% nitrous oxide gas for 1 hour rapidly improved the depressive symptoms that lasted for at least 24 hours. However, some people have side effects such as nausea, vomiting, and headache. I was there. '

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial-PubMed
https://doi.org/10.1016/j.biopsych.2014.11.016

Mr. Nagare thought that the reason why the negative side effects were large at the time of the previous study was that the concentration of the gas used was too high, and in order to reduce the side effects, he used nitrous oxide gas whose concentration was reduced to 25%. We conducted additional research.

As a result, it was confirmed that while the negative side effects were suppressed to one-fourth, the same effect as when using 50% gas was obtained.

The effect of gas administration lasted for a full two weeks. 'It's a very cool discovery,' says Nagare, who has never seen such an effect.