'Vitamin D'reduces severity of new corona in clinical trials

So far, the results of clinical trials have shown that vitamin D, a nutrient that has been discussed for its association with novel coronavirus infection (COVID-19), may reduce the risk of COVID-19 aggravation. It was announced.

'Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study'-ScienceDirect

Finally Confirmed! Vitamin D Nearly Abolishes ICU Risk in COVID-19 | Chris Masterjohn, PhD

Previous studies have found that ' COVID-19 critically ill patients are deficient in vitamin D. ' Therefore, several investigators said that there was a 'relationship between vitamin D deficiency and COVID-19 severity.' There is a research result.

New data and research results showing that it is possible that vitamin D deficiency causes the severity of new coronavirus to vary from country to country-GIGAZINE

However, most of the studies investigating the aggravation of vitamin D and COVID-19 were estimated from the sunshine duration and vitamin D intake status in each region, and a clinical trial of actually administering vitamin D to COVID-19 patients. It wasn't through. Therefore, regarding the effectiveness of vitamin D for COVID-19, there are many skeptical opinions that ' ingestion of vitamin D does not prevent illness ' and many points of concern about side effects.

There is no evidence that ``a large amount of vitamin D is effective for measures against new coronavirus'', pointing out that there are side effects-GIGAZINE

Therefore, a research group such as Marta Entrenas Castillo, who works at the University Hospital of Reina Sofia attached to the University of Cordoba, Spain, conducted a clinical trial of calcifediol administration in COVID-19 inpatients. Calcifediol is a metabolite of vitamin D produced in the liver and is also called '25-hydroxyvitamin D'.

All 76 patients in the trial were treated with the antimalarial drug hydroxychloroquine and the antibiotic azithromycin , and other antibiotics as needed. In addition, 50 randomly selected patients received calcifediol as an experimental group and the remaining 26 control groups did not.

The dose of calcifediol for the experimental group was 0.532 mg (106,400 IU ) on the first day of admission, 0.266 mg (53,200 IU ) 3 and 7 days after admission, and 0.266 once a week until discharge thereafter. It is said that mg was administered by soft capsule.

As a result, none of the patients treated with calcifediol died, all 50 were discharged, and no complications were seen. Meanwhile, half of the 26 patients who were not given calcifediol were discharged safely, while the remaining 13 were taken to the intensive care unit (ICU) , two of whom died. Is that.

The research group positions this clinical trial as a 'preliminary trial,' pointing out that larger trials are needed to provide a definitive answer. The researchers then added in a paper that 'calcifediol could reduce the severity of COVID-19. This preliminary study shows that calcifediol, the major vitamin D endocrine system, High doses of the metabolite 25-hydroxyvitamin D have been shown to significantly reduce the likelihood that patients admitted with COVID-19 will require ICU treatment.' I attached it.

Chris Masterjohn, a former associate professor of health and nutrition science at City University of New York at Brooklyn, said, ``This is the first randomized controlled trial of Vitamin D and COVID-19. It's the most important research I've ever linked.' Regarding the efficacy and side effects of Vitamin D, 'This study was carried out based on the fact that keeping the serum concentration of calcifediol at 30 ng/mL or more is almost completely harmless and beneficial almost without exception. It is irresponsible not to be the definitive proof of the causality of -19.'

in Science, Posted by log1l_ks