It is pointed out that the experiment that created the genetically edited baby failed and caused `` unintentional mutation ''



In 2018, Chinese researcher He Jiankui of Nankata University of Science and Technology used the technology `` CRISPR-Cas9 '' that can freely change the genomic sequence of DNA, `` resistant to HIV by gene editing and was able to produce the twins ' announcement was. He is reported to have been missing since then, but as a result of an expert review of a copy of an unpublished paper, it is reported that 'the study is likely to have failed'.

China gene-edited baby experiment 'may have created unintended mutations' | Science | The Guardian

Scientists slam Chinese gene-edited babies research after manuscript released-CNA

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After the research contents were announced in November 2018, in January 2019 the existence of twins of `` Ru '' and `` Nana '' that were genetically edited was confirmed, Mr. Ga It was reported that it was subject to the investigation. On the other hand, since he attended an international conference in Hong Kong at the end of November 2018 and announced the results of his research, he has not appeared in public. 'Isn't it restrained?'

Chinese scientists who confirmed the existence of genome-edited twins in China and conducted clinical experiments are subject to police investigation-GIGAZINE

Meanwhile, the MIT Technology Review , a science and technology magazine, said that he got a copy of his unpublished paper from an anonymous source at the beginning of 2019. He said he had submitted his paper at least to Nature and JAMA , but both journals refused to publish after examination.

Many criticisms were gathered in his research, but the papers and experimental data were not published, and details remained unknown. Therefore, science writer Antonio Regalado said that unpublished papers were reviewed by legal scholars, in vitro fertilization doctors, embryologists, and gene editing technology experts to investigate the validity of the research. As a result, Mr. Kaga's research has revealed a number of issues, including deviations from ethics and scientific norms.

First, Mr. Ka widely claimed that 'it was possible to give HIV resistance to the baby by gene editing technology', but there was no data that actually succeeded in giving the baby HIV resistance . Some people have a mutation in a gene involved in the immune system called CCR5 , and people with this type of mutation are known to be resistant to HIV. Mr. Ga claimed that the mutation of CCR5 was reproduced by gene editing to make the baby resistant to HIV, but according to the reviewing experts, Mr. Ka said that his attempt was unsuccessful .

He's research team certainly did gene editing targeting CCR5, but it wasn't able to completely reproduce known mutations, and `` mutations that might not lead to HIV resistance acquisition 'The expert pointed out.' Professor Fyodor Urnov, who studies gene editing at the University of California, Berkeley , said, “The claim that they reproduced the mutation in CCR5 is an explicit misrepresentation of actual data, and it can be said to be 'intentional deception' 'I was accused.'



Also, CRISPR is not a perfect tool, and when trying to edit one gene, there are cases where other genes are changed unintentionally. However, it became clear that his research team only examined one of the early embryos to confirm the results of the gene editing, and did not perform comprehensive verification.

In addition to these doubts about the experimental results, it is pointed out that Mr. Kaga's experimental methods and papers may have various deficiencies. For example, the author list of a paper does not include the name of the doctor or obstetrician who was responsible for infertility treatment. This point hurts the reliability of the paper, and it is possible that doctors were allowed to cooperate in the experiment without being informed of the fact that they were 'involved in research on gene editing technology'. There seems to be.

In addition, he said, “The baby's father was HIV-infected and had given up having a child because of his illness, but this experiment gave him a child,” There are still doubts about this. Because HIV is not inherited and develops only by infection with the HIV virus, it is possible to safely give children by simply removing the HIV virus from the sperm by washing the sperm. Reproductive endocrinologist Jeanne O'Brien pointed out that 'the inability of parents to receive infertility treatment due to social circumstances in China may have motivated them to participate in this experiment.' did.

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