Successfully remodeled to see the infrared light that should not be seen by injecting nanoparticles into the eye of the mouse
Normally, humans perceive long wavelength light as red light, but 760 to 830 nanometers is the upper limit of light that humans can perceive, and light of longer wavelength can not be perceived. Light of a wavelength that is too long to perceive is called infrared light, and not only humans but also many mammals such as mice can not feel the infrared, but Chinese researchers can not detect special nanoparticles in mouse retina I reported that I succeeded in remodeling the mouse so that I can see infrared light which should not normally be seen by attaching it.
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There are organs that detect infrared rays in snakes and some fish in the natural world, but humans and mice can not sense infrared rays. On the other hand, if you use infrared cameras or wear special goggles, you can see infrared rays even by humans, in the past you used a special contact lens that can sense infrared and went on a poker in a casa Has also been reported.
Ikasama will be held at poker with infrared contact lens - GIGAZINE
A research team led by Professor Tian Xue Life Science of China Science and Technology University developed specialized nanoparticles that convert infrared light into green light that human beings and mice can see. The nanoparticles were designed to attach to photoreceptors on the mouse retina and injected into the eye of the mouse. When infrared light was applied to the eyes of the mouse injected with nanoparticles, the pupil shrank in response to infrared light. This shows that the mouse sensed the infrared light that would normally be invisible and reacted to it.
And the research team put the mouse injecting special nanoparticles and the mouse injecting the solution without nanoparticles as a control experiment into the case with two rooms. Measurement of the dwell time of the mouse with the light in the other room illuminated with infrared light for the other light, the mouse injected with nanoparticles dislikes infrared light, pure darkness He said he liked to spend time in his room. On the other hand, mice that were not injected with nanoparticles did not perceive the infrared light and spent evenly in either room.
In addition, we placed the mouse in a Y-shaped case containing water in a bright place and conducted experiments as to whether or not the mouse noticed in a safe space indicated by infrared light, whereupon the mouse injected with nanoparticles was safe I was able to notice the space. However, mice that were not injected with nanoparticles did not notice a safe space.
The nanoparticles used by Mr. Xue were not originally made for the purpose of letting the mouse recognize infrared light. Since the beginning of the 21st century, biological researchers have devised a method of injecting light-sensitive molecules into neurons and have created a field of light genetics that controls living cells by light . It seems that light genetics will advance many scientific researches and can be applied to the treatment of brain diseases.
Light sensitive molecules used for such genetics respond to blue or yellow light, but these lights are blocked by the skin and muscle of the creature. Therefore, it is necessary to use an invasive optical fiber to manipulate the light genetics, or to embed an LED device in the living body. On the other hand, the near infrared light is only a few millimeters, but it is possible to go through the living body, and it seems that it has the possibility to make operation in light genetics easier.
So Mr. Gang Han of the University of Massachusetts Medical School has developed nanoparticles that absorb infrared light and emit green light which is visible light. A noninvasive new photogenetic method using nanoparticles that cause photoconversion is published by a research group such as RIKEN .
When Mr. Han talked about this nanoparticle with Mr. Xue who was studying mouse vision, he said that he had the question "What if we inject this nanoparticle into the eye of a mouse?" Han then reinforced the nanoparticles with a protein called concanavalin A to attach the nanoparticles to the retina and injected into the eye of the mouse, it seems that a layer of nanoparticles was formed on retinal photoreceptors.
This research makes it possible to "convert infrared light into green light", and the mouse inherently does not recognize infrared light as infrared light, but instead of recognizing infrared light with ordinary green light It is thought that you will not be able to tell the difference. Lan Yue, an ophthalmologist at the University of South Carolina, says, "It is very interesting whether the mouse can recognize infrared light without the confusion with green light."
Mr. Han said, "Infrared goggles are heavy and require batteries," I believe that by acting directly on the retina it is possible to identify infrared light better than before. "By taking eye drops containing nanoparticles, you may be able to recognize a special infrared light pattern visible only to that person," Han said.