The possibility that a person can wake up the ability to regenerate a severed limb is being shown from the study of Wooperaar

by Tambako The Jaguar

Mexican salamander (wooper looper) is familiar to being loved as a pet or to be fried . Because wooper looper has a marvelous ability to regenerate even when cutting extremities, it is also treated as research subject. It is believed that there is a possibility that it will greatly affect cancer treatment as well as treatment of those who lost a part of the body by advancing Woeper Looper's research. Quanta Magazine of science media summarizes the current state of Wooperaughar research that may arouse human reproduction ability.

Axolotl Genome Slowly Yields Secrets of Limb Regrowth | Quanta Magazine
https://www.quantamagazine.org/axolotl-genome-slowly-yields-secrets-of-limb-regrowth-20180702/

The healing and regenerative ability of wooper looper is completely different from that of human being. When a human being is injured, scars are instantly created by macrophages and the organization is not regenerated. On the other hand, in the body of Woopera Rapper macrophages take in dead cells, plus the cell group of the young embryo " shoots " play a role in regenerating the cut arm and heart. For that reason, Wooper looper will play the entire arm when cutting is done from the shoulder, forearm and hand when it is disconnected from the elbow, and only the hand when the wrist is cut.

Research is continuing even now that it may be possible to arouse a human's regenerative ability by continuing Woeper Looper's research.

You can read the details from the following article on the history that Wooper Robber became the subject of research and why the number of individuals is concerned about reduction.

It will be key to rescuing "wooper roper" in order for human being to be able to play even if the limbs are cut - GIGAZINE

In order to read the sequence of the genome of a living thing, scientists have to fragment DNA and then assemble them like a jigsaw puzzle. The genome of Wuparlooper is more than 10 times more than the human genome, 32 billion base pairs, and it has not been decoded until recently due to its large number. However, as technology has greatly advanced with the power of computers and latest algorithms, in 2018, an international research team such as Germany succeeded in decoding the genome of Woopera River. It seems that it is the largest in the genome of organisms decoded so far.

◆ How does the genome of Woopera Rapper help medical care?
Analysis of the genome of Woeper Looper makes it one step closer to the answer to the question "How can animals regenerate the body?" However, although I know a special gene that regenerates the body of Wu Pauloper, I still do not know if the human body will be well controlled when it is applied to human beings, for example. Elly Tanaka of the Institute for Molecular Pathology, a member of the research team that analyzed the genome of Wooperall, said, "The paper merely shows the genomic sequence to other researchers, From now on for the realization to understand, which will take several years. "

On the other hand, Mr. Tanaka says that "In the regeneration of limbs, a relatively large number of genes thought not to be found in humans can be found in Wooperarooper", and the investigation of these genes is followed by " It may be a way to success ".

Responding to the fact that the genome research of Wooper has entered a new era, in the summer of 2018 researchers from around the world will be gathering in Vienna, Austria. How to use the genome sequence and other resources, and plan to assign new researchers to the study of Wooperaar etc. James Monaghan of North Eastern University says, "Two genome assemblies are possible, and molecular tools are also being developed at various laboratories and this genome is truly a standing gate at the start." 2018 7 I am talking about the current situation of the month.

Monaghan is trying to use it for the treatment of stem cells to be applied to the human eye weakened by aging by studying the retina of Wooper looper. He also said that Mr. Monaghan believes that the speed of lung regeneration will be helpful in treating human lungs. In addition, some researchers have made indicators to measure the healing response of mice who underwent cutting surgery by clarifying which proteins are important for regeneration of the extremities of Wooperper. Finally, this study may help doctors to predict who will recover among those patients forced to have limb amputations.

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Furthermore, since the regenerated tissues of Wooperaaru are similar in many respects to cancer cells, by studying how the tissue environment of the regenerated limbs of Wooperaaru controls the cells, the surrounding of cancer cells It seems that there is a possibility that it can also force "to behave like usual" by controlling the environment of. However, the fact that there is a connection between "regeneration of organization" and "cancer" can be grasped in a bad direction. Frequent regeneration of limbs may increase the risk of carcinogenesis. However, regarding this point, Jessica Whited, Associate Professor at Harvard Medical School of Medicine, said, "Interestingly, Wooperaar seldom gets cancer even if you regenerate your body." "On the other hand, It depends on it. "

Actually, in 1952, a scientist Charles Breedis made an experiment to inject coal tar etc. known as a carcinogen in more than 500 newt's arms. Both newts and wooper looper are the same amphibian, and newts have the same regenerative ability as Wooper ropers. Experimental results showed that among the 500 animals there were 2 tumors and the rest showed a reaction to grow "additional arms". Understanding why carcinogenic substances produce such responses should have a major impact on the field of cancer treatment.

I do not know why Wooper Rap was acquired in the process of evolution, or why other animals lost this ability in the course of evolution. Many researchers say that the ability to regenerate is "what many animals have lost in the process of evolution", but on the other hand, focusing on the relationship with "regeneration of the tail" that ancient organisms had There are also some researchers. However, there is also a view that playback of the tail occurs on an extension of the axis of the body and is different from "reproduction of limbs" like Wooperall.

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If many of the ancient creatures had regenerative capacity, there may be hints in "genetic withdrawal" that our human descendants have. Some people forced to cut limbs can not control the growth of nerve fibers and a tumor called a neuroma is formed. There is also a view that it is a remnant of regenerative ability. According to his research, Mr. Whited believes that humans have more regeneration capacity than is permitted in the year 2018, and if the body is put in an appropriate state, I think that there is a possibility to be able to play.

The above possibility is agreed with other researchers, and Mr. Tanaka does not exclude the possibility. While preamble saying, "It is a little difficult to understand how complicated it is, it is a little difficult", but research that arouses the human's ability to regenerate is "worth the effort I think is worth it "Tanaka said.