Research results showing that the surge of lethal infectious diseases was actually caused by artificial sweetener "trehalose"

byCalebe Miranda

In the past there was no severe patient so far but in recent years it has become a violent revolution, bacteria that cause nearly 30,000 deaths in a year are "Clostridium · difficile". Antibiotics do not work "Super BugAlthough it was thought that the relation with artificial sweetener is also the latest researchTrehaloseShowed the possibility of causing a sudden increase in the number of patients.

Pathogens boosted by food additive
https://www.nature.com/articles/d41586-017-08775-4

Dietary trehalose enhances virulence of epidemic Clostridium difficile | Nature
https://www.nature.com/articles/nature25178

Quirks & amp; Quarks with Bob McDonald | CBC Radio
http://www.cbc.ca/radio/quirks/this-food-additive-is-hard-to-avoid-and-could-make-hospital-superbugs-more-deadly-1.4470200

Mysterious explosion of a deadly plague may come down to a sugar in ice cream | Ars Technica
https://arstechnica.com/science/2018/01/the-curious-case-of-a-boring-sugar-that-may-have-unleashed-a-savage-plague/

Patients have increased rapidly in the United States since around 2000Clostridium · difficile enteritisAlthough it was not initially believed to be a dangerous infection so far, it suddenly suffered a serious diarrhea as a serious diarrhea, and in 2011 there are as many as 500,000 patients a year, of which about 29,000 He died.

byCenters for Disease Control and Prevention

I investigated "Why did it suddenly became a threat" about that RT027 strain and RT078 strain which are considered lethal among its Clostridium difficile, and found out surprising thing.

"Super bug" where antibiotics do not workThere are also reports that it is reported as news, and some researchers claim the relationship between Clostridium difficile and super bug. However, according to a study newly announced at Nature, the change in C. difficile is not used as a bacterial gain of new weapons, nor is the antibiotic's weak power, it is used as a sweetenerTrehaloseIt is said that it is seen as being in.

The research team of Professor Robert Britton of Baylor College of Medicine et al. First analyzed genes of RT027 strain and RT078 strain among Clostridium difficile. As a result, we discovered that the two strains are enhanced using low concentrations of trehalose. In addition, strains other than the above are considered not to use trehalose.

Subsequently, researchers conducted experiments using mice. Mice were infected with RT027 and RT027 with genetic modification so as not to be able to metabolize trehalose and given cold water in which trehalose was dissolved. Then RT 027 ordinary killed 80% of the whole mouse, but the mortality rate by RT 027, which can not metabolize trehalose, was only 33%. Afterwards, trehalose water and ordinary water were given to mice infected with RT027 which had not been altered in the gene, and it seems that the mortality rate of mice fed trehalose water was three times that of the comparative group. In the experiment, it was said that trehalose seemed to produce more poison than raising fertility of RT 027.


Likewise, for RT078, we compared the one that can metabolize trehalose with one that can not be metabolized, and simulate the infection of C. difficileBioreactorThe former who was given low concentrations of trehalose in the inside showed that it showed more reproductive power than the latter.

Trehalose is confirmed in many animals and plants and microorganisms in the natural world, but it was not used much in the food industry in the past because of its high manufacturing cost. However, it is a Japanese biomakerRyuujiEstablished an inexpensive mass production method from starch. By 2000, when Clostridium · difficile enteritis patients begin to increase rapidlyAmerican Food and Drug AdministrationIt was decided that it was often used as a sweetener as food because it was approved for use in foods in Europe the following year.

byLAWJR

From these experimental results and historical data, researchers have mutated trehalose in food so that bacteria can utilize trehalose, and Clostridium · difficile is raging in the presence of trehalose I think that it might have come to wake up. However, it is unknown at the time of article writing whether or not Trehalose is at a level that will affect RT027 and RT078 in the human body, and further research is required.

As in RT 027, antibiotic-deficient bacteria are considered superbugs, thought to be resistant due to antibiotic abuse, but the results of this study are not common antibiotics but rather mediocre "sweetener "The biggest point is suggesting the possibility that the intestinal environment was disturbed. Food additives are now widely used in the food industry, but there is a possibility that we are guiding results that we do not anticipate.