Is it "effective to go to the farm" to prevent allergies and asthma from occurring?

ByAsian Development Bank

It seems that children raised on farms are less likely to cause "asthma" than children of the same generation, and the probability of having allergy of respiratory system is also low, but the reason is that " Bacteria included in dust "SciencePublished inpaperIt was clarified by. From this fact, the possibility that a new method to eliminate asthma and allergy in the future will be born is rising at a stroke.

Farm dust and endotoxin protect against allergy through A 20 induction in lung epithelial cells
http://www.sciencemag.org/content/349/6252/1106

Here's why farm kids have fewer allergies and less asthma | The Verge
http://www.theverge.com/2015/9/3/9256955/allergies-asthma-farm-kids-dust-endotoxins-a20

Allergy of the respiratory system is one of the most common allergy of Americans' children, and it seems that 17% of the whole has allergy of some kind of respiratory system. Furthermore, there are about 6.8 million children with asthma in the United States, and research to suppress respiratory allergy and asthma has been regarded as important.

In a paper published in Science, it was discovered that "not all symptoms of allergy are evenly occurring in all children" as we conduct survey on respiratory allergies and asthma. In the further survey we have discovered the fact that "children raised on the farm have a very low probability of having allergies and asthma". In particular, children of dairy farmers said they had a particularly low probability.

ByU. S. Department of Agriculture

So researchers advanced the environmental survey on the farm, and it turned out that children raised in rural areas protected their bodies from allergies and asthma by a certain mechanism. And this mechanism is that children can live in urban areas with drugs.

The experiment conducted by the researchers is to expose rats to "endotoxin" which is a piece of dying bacteria contained in farm dust and cattle manure fertilizer, for 2 weeks, and then "rodent dust mite allergies" It is to expose it to. As a result of this experiment, it has been found that mice exposed to endotoxin did not cause asthma or allergy caused by dust mites and the like.

By carrying out further detailed experiments, researchers have included a molecule called "A20" in the lungs of mice exposed to endotoxin, and this molecule acts on lung cells to induce an immune reaction caused by allergies and the like I have found that it suppresses it. In the study, in order to confirm whether "A20" is a key molecule to regulate the immune response, we grown a mouse that does not contain "A20" in lung cells, and an experiment in which this rat is exposed to farm dust and endotoxin We are doing. In this experiment, rats without "A20" became asthmatic, from which it was revealed that dust on the farm reacted to "A 20" in the lungs to protect themselves from allergies and asthma .

ByNIAID

Experiments on whether or not similar reactions occur in human lungs after demonstration experiments with rats have been conducted and it has been confirmed that immune responses are reduced even in lung cells of people exposed to endotoxin. However, it has been found that when asthma has already been developed in people lung cells are cultured and exposed to endotoxin, an allergic reaction of asthma occurs, which is "sufficient for asthmatic lung cells It suggests that "A20" is not generated. "

Furthermore, by investigating data on children (6 to 12 years) of European farmers for 1,700 people gathered in another study, children suffering from respiratory allergy suffer from "A 20" molecules disappearing It has also been shown to have genetic variants.

ByNIAID

Mr. Bert Lambrecht who works as a respiratory physician at Ghent University in Belgium and his research team presented the paper. Mr. Lambrecht commented that "If you take advantage of this reaction, you can make allergies not occur completely", but this is only because "A20" is working at a high level in the lung In the case of the case, there may be no effect at all if genetically "A20" is hardly produced. As for the phenomenon that "A20" and dust on the farm interact with each other, "This is a completely new mechanism that can protect the body from allergies," Rambrecht said.

On the other hand, research has shown that even if a person with asthma already exposed to endotoxin can not suppress the immune reaction caused by allergy, even if it does not cause asthma or respiratory allergy Even if we developed a medicine that applied "reaction of A20 and endotoxin" in order to do it, it will not work for children over 2 and 3 years old. On the contrary, as the endotoxin level increases, the symptoms of asthma become unstable, so there are still a lot of obstacles to make use of this new finding to completely eradicate asthma and respiratory allergy It can be said.

However, in the study, it is said that small children under age two and three years of age sucking in farm air will be an effective means to protect themselves from asthma and allergies, Mr. Lambrecht said, "This research has children on the farm It shows that there is no need to be afraid to send it to a childcare center etc. "