Jogging and cycling affects muscle metabolic function at the gene level

ByJeff Drongowski

It is the world's largest research institute in medicine, the Swedish selection committee of the physiology and medicine department of the Nobel PrizeKarolinska Institute, It was found that durable training such as jogging and cycling over a long period of time affects muscle metabolism function at the gene level.

An integrative analysis reveals coordinated reprogramming of the ep ... - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/25484259

Long-term endurance training impacts muscle epigenetics - Karolinska Institutet
http://news.cision.com/karolinska-institutet/r/long-term-endurance-training-impacts-muscle-epigenetics,c9693593

Long-term endurance training impacts muscle epigenetics | News | News | Karolinska Institutet
http://ki.se/en/news/long-term-endurance-training-impacts-muscle-epigenetics

It is clear from previous studies that moderate exercise benefits health, the interest in people's health care and exercise has risen, and in recent years even IT companies such as Apple and Google have been concerned with health devices and applications It is about to release. However, it has not been clarified how the health effects that the body exerts by exercise are caused, its mechanism.

ByJason Lengstorf

The research team of the Karolinska Institute is to clarify the mechanism on the body's effects on exercise at the genetic level. In the studies conducted, endurance training conducted over a long period is part of muscleSkeletal muscleofEpigeneticsIt was found that the level of occurrence was changed.

Epigenetics is a biochemical change caused by various environments within genetic information constituting a human being. In brief, if the gene is cellular hardware, epigenetics is cell software etc. One of its epigeneticsDNA methylationThere is something called. DNA methylation is a process in which original DNABase sequenceWithout affectingMethyl groupIs a chemical reaction that is added to or removed from a DNA molecule.

ByMatthew Forsythe

In the experiment conducted by the research team, we asked 23 healthy men and women to cycle cycling with only one foot four times a week for 3 months, and after the cyclingMetabolism of skeletal muscle"genomeOccurrence state of DNA methylation at 48,000 sites in"Activity state of more than 20,000 genes"Is measured. As a result of experiments, strong association was confirmed with "DNA methylation" and "activity change of 4000 genes".


According to the research team, it was found that the genes related to the region in the genome where the incidence of DNA methylation occurred was related to the metabolic function of skeletal muscle.

In other words, it was found that the reaction which raises the metabolic function of skeletal muscle by exercise occurs at the DNA level. Dr. Johan Sundberg, who led the experiment, said, "From the experimental results it turned out that endurance training such as jogging and cycling had a major influence on genes related to improving muscle function and health. He has the potential to deepen understanding of diabetes and heart disease and establish a treatment method and may also clarify how to maintain muscle health status, Further expectations will be applied to future research.