`` Ketone diet '' that avoids carbohydrates by taking a lot of fat increases immunity against influenza
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The ketonic diet , which avoids sugar and sweet fruits in general and starch-rich foods as much as possible, and consumes as much energy as possible from fats such as nuts and butter, is a popular carbohydrate-restricted diet. Experiments with mice have shown that this ketone diet is effective in preventing influenza infection.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection | Science Immunology
https://immunology.sciencemag.org/content/4/41/eaav2026
Ketogenic diet helps tame flu virus | YaleNews
https://news.yale.edu/2019/11/15/ketogenic-diet-helps-tame-flu-virus
Eating a keto diet may give some protection against the flu | New Scientist
https://www.newscientist.com/article/2223688-eating-a-keto-diet-may-give-some-protection-against-the-flu/
A ketone diet that avoids carbohydrates as much as possible and consumes enough protein and large amounts of fat was developed in the early 1920s as a treatment for epilepsy. In recent years, a ketogenic diet has attracted attention as one of the treatments and diets for obesity, but in a new study, mice fed the ketogenic diet have higher immunity to influenza than mice that ate a high carbohydrate diet It was shown that.
This research project is a professor at Yale University Graduate School of Medicine, a researcher at Howard Hughes Medical Research Institute, Akiko Iwasaki, and a professor of comparative medicine and immunobiology, Vishwa Deep Dixit. Based on raw ideas.
Mr. Ryan Molony, one of the inventors and working in Mr. Iwasaki's laboratory, is a person who originated that `` Inframasole '', an activator of the immune system, shows a harmful immune response to the human body Emily Goldberg, who worked in Dixit's lab, discovered that a ketogenic diet inhibits the formation of inflammasole. They wondered what effect the ketone diet would have on the immune system's response to pathogens such as influenza and devised a project.
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In order to verify this question, researchers have tested two groups of mice that received a `` standard ketone diet '' and a `` standard diet high in carbohydrates '', and influenza A is considered to have the most severe symptoms of influenza. I tried to infect it with a virus . Then, 7 mice fed the standard diet were all infected with influenza 4 days after the start of the experiment, whereas only 5 out of 10 mice fed the ketone diet were infected with influenza. I was told. In addition, as a sign that the animal was infected with influenza, 'loss of body weight' can be mentioned, but it seems that there was no decrease in body weight in mice fed a ketone diet.
Research has shown that the ketogenic diet activates γδ T cells in the lungs. γδT cells are thought to prevent infection by increasing the sensitivity of lung cells to disease infection and producing mucus.
Mr. Iwasaki described this research result as 'unexpected discovery'. Mr. Iwasaki believes that mucus is important for protecting the body from pathogens because it catches pathogens and prevents their spread. Of course, metabolism is different between humans and mice, but it is possible that the ketone diet protects humans from influenza viruses as well as mice.
Based on the results of this research, John Tregoning, an immunologist at Imperial College London, has confirmed that the connection between the diet and the immune system has been confirmed by taking the example of vitamin C strengthening the immune system as an example Explained. Like vitamin C, Tregoning said that a ketogenic diet has the potential to improve the immune system to fight infection.
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