Fisetin, a substance that can extend healthy life span, is contained in vegetables and fruits

by Jez Timms

Researchers who announced the existence of a treatment capable of reducing the number of damaged cells called "senescent cells", extending the life span and improving the health condition in July 2018 newly added " ficetin " I succeeded in greatly improving the life expectancy and health condition of an old mouse by a naturally derived substance called.

Fisetin is a senotherapeutic that extends health and lifespan - EBioMedicine
https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext

Researchers have discovered how to slow aging: Natural product found to reduce the level of damaged cells in the body, caused by aging - ScienceDaily
https://www.sciencedaily.com/releases/2018/10/181002114024.htm

The damage accumulated by the cell accumulates as a person grows older, but this damage reaches a certain level or the necessary constituent elements are deficient, so cell division and growth stops. This process is called cellular aging . When senescence occurs, the cell releases a substance called an inflammatory factor in order to send the message "Remove the damaged cells" to the immune system. Although young people remove senescent cells by the immune system, aged cells can not successfully remove senescent cells, accumulated senescent cells cause chronic inflammation and enzymes that degrade tissues are released It will be like.

Paul D. Robbins and Laura J. Niedernhofer of the University of Minnesota - Medical School, and James L. Kirkland and Tamara Tchkonia of the Mayo Clinic have accumulated a substance called "fisetin", which is rich in vegetables and fruits Have reduced the level of senescent cells that have been treated. When researchers administered fisetin to elderly mice, health condition was improved and lifespan was extended.

"This result shows that we can extend the duration of what we call" healthy life "even if it is from the end of life, but the question to be solved, such as the dosage of the appropriate substance, There are still a lot left out, "Robbins said.

by Vlad Sargu

Until now, there were limited ways to identify how specific drugs and substances work against different tissues and different cells. It is difficult to ascertain whether only one senescent cell is being attacked by one therapy, so the effect of fisetin has not been announced so far. However, with the cooperation of engineers from the University of Minnesota, it was confirmed that the effect of fisetin was confirmed for the first time by introducing a special technique called " CyTOF Mass Cytometry Measurement Consignment " to aging research.