Successfully prolonged prolongation of progeria mice possible to rejuvenate "aging" in the application of iPS cell production technology

ByMaurits Verbiest

A report that "aging" can be "reversed" by reprogramming genes was published in the academic journal "Cell" dated 15th December 2016. Actually, I succeeded in life prolongation by 30% in the mouse. What became the key to this research was the four factors (Yamanaka factor) introduced by professor Shinya Yamanaka when making iPS cells.

In Vivo Amelioration of Age - Associated Hallmarks by Partial Reprogramming: Cell
http://www.cell.com/cell/fulltext/S0092-86741631664-6


Scientists Say the Clock of Aging May Be Reversible - The New York Times
http://www.nytimes.com/2016/12/15/science/scientists-say-they-can-reset-clock-of-aging-for-mice-at-least.html

Scientists reverse ageing in mammals and predictive human trials within 10 years
http://www.telegraph.co.uk/science/2016/12/15/scientists-reverse-ageing-mammals-predict-human-trials-within/

IPS application, extended life of mouse ... US research team: science · IT: Yomiuri Shimbun (YOMIURI ONLINE)
http://www.yomiuri.co.jp/science/20161216-OYT1T50013.html

The discovery of this timeSoak InstituteThrough research team of.

"Aging" is an irreversible phenomenon that gradually weakens the cells of the body, but even if the parents' germ cells are old, the fertilized egg always begins from the state of "0 years old" is a mystery of biology It was one. However, it was led to this discovery that I thought that "aging is not irreversible and it is possible to unwind the body clock".

In 2006, the research team introduced four factors (Oct 4, Sox 2, Klf 4, c - 1) known as "Yamanaka factor" introduced by Professor Yamanaka Shinya of Kyoto University Research Center for Regenerative Medicine Science (then) Myc: OSKM). In the research, we found that reprogramming partially improves "aging" of cells.

ProgeriaThe mice were verified and the lifespan of 18 mice who did not take measures was 18 weeks in average, whereas the lifespan of 15 mice who took measures was extended to an average of 24 weeks. It seems that improvement in metabolism and muscle damage has also been seen.

Even in human skin cells, it has been confirmed that it has a rejuvenating effect, but this is an experiment in vitro and it is estimated that it will take another 10 years until clinical trials.

Various studies aiming for "rejuvenation" are underway and reallyIf you can live for another 30 years you will realize a lifespan of 1000 yearsI think that it may be done ... ....